Plain-language, educational articles on schizophrenia, psychosis, antipsychotic medications, and lived experience — by ColdAI.
Extrapyramidal symptoms are the family of movement side effects produced by dopamine-blocking medications. Understanding the four sub-types — and how they overlap — changes how they get treated.
Drug interactionsCaffeine is the most commonly consumed psychoactive substance in the world — and it shares a metabolic pathway with several antipsychotics. Here is what to actually know.
Brain circuitsThe hippocampus is one of the most consistently affected brain regions in schizophrenia. Smaller volumes, regional hyperactivity, and CA1 dysfunction appear early and may help drive dopamine abnormalities downstream.
Expressive therapiesArt therapy is more than 'doing art.' It is a structured psychological therapy in which images become a way to think about experiences that are hard to put into words.
HousingSupported housing is not one thing — it is a spectrum of arrangements ranging from a private apartment with a visiting case manager to a fully staffed group home. Choosing the right rung matters enormously.
SleepSleep in schizophrenia is not just disturbed — its architecture is measurably different. Reduced slow-wave sleep, fewer sleep spindles, and shifted REM are now well documented in the literature.
ResearchGenome-wide association studies have identified hundreds of genetic loci linked to schizophrenia. Here is what those findings mean — and what they still cannot tell us.
Medical comorbidityType 2 diabetes is two to three times more common in people with schizophrenia than in the general population — and it is dramatically under-screened, under-diagnosed, and under-treated.
MedicationChlorpromazine, sold as Thorazine in the US and Largactil in Europe, was the first antipsychotic and remains a working option in 2026 — usually for specific situations rather than first-line use.
MedicationChlorpromazine started the modern era of antipsychotics in 1954. Its side effect profile is broad and well-mapped — sedation, low blood pressure, dry mouth, sun sensitivity, and more.